This paper examines the arrest trajectories of adult men and women, drawn from a sample of clients admitted to substance abuse treatment. Growth mixture modeling was used to identify distinctive trajectories in arrests for men and women between ages 18 and 45. In addition, the characteristics of men and women in each of the trajectory groups were compared by gender, arrest trajectory, and the interaction of gender and arrest trajectory. Findings indicated that while the shape of the five trajectories was similar for men and women, higher percentages of men than women were in the High trajectory group (12.5% vs. 8.5%), the Moderate group (27.9% vs. 20.9%), and Slow Increase group (25.5% vs. 20.6%), with more women than men being in the Low group (34.1% vs. 27.1%). Although arrests declined as men and women aged, there did not appear to be many individuals who had terminated their criminal career by age 45. Overall, more similarities than differences were observed in the characteristics of men and women across trajectories. Additional research should examine whether the causal factors influencing arrest trajectories differ by gender.