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Elsevier, Journal of Biotechnology, (195), p. 93-102, 2015

DOI: 10.1016/j.jbiotec.2014.12.023

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Development of a hazel cell culture-based paclitaxel and baccatin III production process on a benchtop scale

This paper is available in a repository.
This paper is available in a repository.

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Abstract

The growing demand for the antitumorous agent paclitaxel and the difficulty in increasing its production by genetic engineering has prompted a search for new sources of taxanes. It has been reported that taxanes can be extracted from the angiosperm Corylus avellana L. Our aim was to improve taxane production by scaling up the process from mL-level to benchtop bioreactors, optimizing culture conditions and comparing the effect of two elicitors, 1 μM coronatine (Cor) and 100 μM methyl jasmonate (MeJA).