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Wiley, European Journal of Clinical Investigation, 4(41), p. 423-433, 2010

DOI: 10.1111/j.1365-2362.2010.02426.x

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Application and validation of a diagnostic algorithm for the atherogenic apoB dyslipoproteinemias

Journal article published in 2010 by Suzanne Holewijn, Allan D. Sniderman, Martin den Heijer ORCID, Dorine W. Swinkels, Anton F. H. Stalenhoef, Jacqueline de Graaf
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

BACKGROUND: We applied a diagnostic algorithm using apolipoprotein B (apoB) in combination with triglycerides (TG) and total cholesterol to determine the prevalence of dyslipoproteinemias in the general population. We also characterized the overall cardiovascular (CV) risk profiles, including arterial structure and function as measured with a panel of noninvasive parameters. DESIGN: Clinical and biochemical characteristics and noninvasive measurements of atherosclerosis (NIMA) were determined in 1517 individuals, aged 50-70 years. RESULTS: In general, all dyslipoproteinemias were characterized by a worse CV risk profile and deteriorated outcomes of NIMA compared to those with normal apolipoprotein B (