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Elsevier, Schizophrenia Research, 1-3(154), p. 79-82

DOI: 10.1016/j.schres.2014.01.038

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No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset

Journal article published in 2014 by Elizabeth A. Heron, Paul Cormican, Gary Donohoe, Francis A. O’Neill, Kenneth S. Kendler, Brien P. Riley, Michael Gill, Aiden P. Corvin, Derek W. Morris ORCID
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Abstract

Runs of homozygosity (ROH), regions of the genome containing many consecutive homozygous SNPs, may represent two copies of a haplotype inherited from a common ancestor. A rare variant on this haplotype could thus be present in a homozygous and potentially recessive state. To detect rare risk variants for schizophrenia, we performed an ROH analysis in a homogeneous Irish genome wide association study (GWAS) dataset consisting of 1606 cases and 1794 controls. There was no genome-wide excess of ROH in cases compared to controls (p = 0.7986). No consensus ROH at individual loci showed association with schizophrenia after genome-wide correction.