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Hormone Receptor Status Defines Survival and Metastasis Rate in Breast Cancer

This paper is available in a repository.
This paper is available in a repository.

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Abstract

Triple Negative (TN) breast cancer has few treatment alternatives. The chance for cure is poor, prognosis is bad and it is more aggressive than other types of breast cancers. Axillary involvement and early solid organ metastasis especially internal organs are more frequent. TN breast cancer with less treatment alternative was compared to divulge the differences with Luminal B (LB) which showed better outcomes with new treatment protocols. Comparison of these two groups may help us to produce promising treatment and follow up protocols. In Ege University General Surgery Department 91 TN (estrogen negative, progesterone negative and human epidermal growth factor negative) and 183 LB (estrogen positive, progesterone positive and human epidermal growth factor positive) patients operated between 1998 and 2007 were included in this study Survival without metastasis were lower than in TN group than LB group at 12th and 24th months but these were statistically indifferent. At 36th and 60th months however differences were significant (Log Rank p=0.021 and p=0.041 respectively) TN phenotype has negative prognosis due to the effect of early high internal organ metastasis rate. This finding has a strategic importance in treatment and follow up approach Key Words: Breast cancer, Triple negative breast cancer, Luminal type breast cancer