The marketing and promotion of tourist sites through modern technologies such as geographic information system (GIS) and dynamic web technologies are slow in developing countries. This paper explores the potential of GIS in marketing tourism and examines how this can influence tourists' destination choice. The study mapped 41 tourist destination spots and ranked 10 of them. The study finds that the middle belt of Ghana has the highest diversity of tourist attractions. The spatial mapping revealed that nine of the 10 most visited destinations are located in Southern Ghana with the remaining in Northern Ghana. This finding is useful in guiding policy-makers towards enacting policies that will boost sustainable tourism in the south while effectively developing the potentials of the north. The study recommends the development and adoption of competitive marketing strategy using geospatial tools directed at meeting the needs of global tourist while integrating local participation.