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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 6(57), p. 2828-2830, 2013

DOI: 10.1128/aac.02211-12

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Activities of First-Choice Antimicrobials against Gamma Interferon-Treated Chlamydia trachomatis Differ in Hypoxia

Journal article published in 2013 by Kensuke Shima, Matthias Klinger, Werner Solbach ORCID, Jan Rupp
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Gamma interferon (IFN-γ)-mediated host responses play a central role in resolving genital Chlamydia trachomatis infections but may also result in persistence of the pathogen, which shows reduced susceptibility to antimicrobials. The antichlamydial function of IFN-γ is oxygen dependent, and the efficacy of antimicrobials against C. trachomatis is reduced in a low-oxygen environment. In this study, we show that the antichlamydial efficacies of azithromycin and doxycycline differ in IFN-γ-treated cells under hypoxia.