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American Institute of Physics, Applied Physics Letters, 1(102), p. 013119

DOI: 10.1063/1.4774291

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Enhancing the tumor discrimination using antibody-activated magnetic nanoparticles in ultra-low magnetic fields

Journal article published in 2013 by H. C. Yang, K. W. Huang ORCID, S. H. Liao, H. E. Horng, J. J. Chieh, H. H. Chen, M. J. Chen, K. L. Chen, L. M. Wang
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

In this paper, we report an enhanced liver tumor discrimination for rats using antibody-activated magnetic nanoparticles (MNs) and ultra-low-field magnetic resonance imaging ex vivo. It was found that the intensity ratio between the magnetic resonance image of tumor and normal liver tissues is 2–3 absence of antibody-activated MNs in rats. The intensity ratio rises to ∼100 when antibody-activated MNs are expressed in liver tumors through vein injection. Enhancing tumor discrimination using antibody-activated MNs is demonstrated using T1-weighted contrast imaging in ultra-low magnetic fields.