American Chemical Society, Organic Letters, 1(16), p. 266-269, 2013
DOI: 10.1021/ol403241v
Wiley-VCH Verlag, ChemInform, 23(45), p. no-no, 2014
Full text: Unavailable
A novel macrolide, callyspongiolide, whose structure was determined by comprehensive analysis of the NMR and HRMS spectra, was isolated from the marine sponge Callyspongia sp. collected in Indonesia. The compound features a carbamate-substituted 14-membered macrocyclic lactone ring with a conjugated structurally unprecedented diene-ynic side chain terminating at a brominated benzene ring. Callyspongiolide showed strong cytotoxicity against human Jurkat J16 T and Ramos B lymphocytes.