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American Chemical Society, Organic Letters, 1(16), p. 266-269, 2013

DOI: 10.1021/ol403241v

Wiley-VCH Verlag, ChemInform, 23(45), p. no-no, 2014

DOI: 10.1002/chin.201423215

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Callyspongiolide, a Cytotoxic Macrolide from the Marine Sponge Callyspongia sp.

Journal article published in 2013 by Cong-Dat Pham, Rudolf Hartmann, Philip Böhler ORCID, Björn Stork, Sebastian Wesselborg, Wenhan Lin, Daowan Lai, Peter Proksch
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

A novel macrolide, callyspongiolide, whose structure was determined by comprehensive analysis of the NMR and HRMS spectra, was isolated from the marine sponge Callyspongia sp. collected in Indonesia. The compound features a carbamate-substituted 14-membered macrocyclic lactone ring with a conjugated structurally unprecedented diene-ynic side chain terminating at a brominated benzene ring. Callyspongiolide showed strong cytotoxicity against human Jurkat J16 T and Ramos B lymphocytes.