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American Chemical Society, Biochemistry, 32(51), p. 6263-6265, 2012

DOI: 10.1021/bi300836r

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Anticancer Peptide SVS-1: Efficacy Precedes Membrane Neutralization

Journal article published in 2012 by Diana Gaspar ORCID, Ana Salomé Veiga, Chomdao Sinthuvanich, Joel P. Schneider, Miguel A. R. B. Castanho ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Anticancer peptides (ACPs) are polycationic amphiphiles capable of preferentially killing a wide spectrum of cancer cells relative to non-cancerous cells. Their primary mode of action is an interaction with the cell membrane and subsequent activation of lytic effects, however it remains controversial the exact mechanism responsible for this mode of action. Using zeta potential analyses we demonstrate the interaction of a small anticancer peptide with membrane model systems and cancer cells. Electrostatic interactions have a pivotal role in the cell killing process and in contrast to the AMPs action cell death occurs without achieving full neutralization of the membrane charge.