In this paper, we presented the technology of preparation, as well as quality evaluation methods of the lipophilic gel based on a medium chain triglyceride (MCT) – Miglyol 812. In so doing, glyceryl stearate and glyceryl dibehenate were used as the gelling agents. The compounded gels were analyzed in terms of organoleptic properties, microscopic analysis, and rheological properties (yield point, thixotropy, viscosity at shear rates 10, 100 and 1000 s-1). Following this, two model active substances: hydrocortisone (2%) as the lipophilic one, and oxytetracycline hydrochloride (0,5%) as the hydrophilic one, were incorporated into gels made of Miglyol 812 and 15% glyceryl stearate. After this, the influence of these active substances on the properties of gel was investigated. Moreover, a spectrophotometric method of content evaluation of these substances in a gel was established.