Published in
Nature Research, Nature Medicine, 10(17), p. 1183-1185, 2011
DOI: 10.1038/nm.2493
Links
Tools
Epigenetic tumor suppression by BRCA1
Journal article published in 2011 by
Aneliya Velkova,
Alvaro N. A. Monteiro 
This paper is available in a repository.
Full text: Download
Published version:
archiving forbidden
Data provided by 
Abstract
BRCA1 germline mutations lead to an increased risk of breast and ovarian cancer, but the mechanisms by which the product of this gene functions as a tumor suppressor have remained elusive. Now, analysis of a missense BRCA1 variant shows that it can epigenetically regulate an miRNA implicated in cancer, providing new mechanistic insights (pages 1275-1282).