Published in
Oxford University Press, Metallomics, 7(3), p. 675, 2011
DOI: 10.1039/c1mt00009h
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Synthesis and in vitro insulin-mimetic activities of zinc(ii) complexes of ethyl 2,5-dihydro-4-hydroxy-5-oxo-1H-pyrrole-3-carboxylates
Journal article published in 2011 by
Hikaru Kawarada,
Yutaka Yoshikawa,
Hiroyuki Yasui 
,
Shunsuke Kuwahara,
Yoichi Habata,
Ryota Saito
,
Shunsuke Kuwahara,
Yoichi Habata,
Ryota Saito
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Abstract
Several Zn(II) complexes (2a-e) of 1-arylmethyl-2,5-dihydro-4-hydroxy-5-oxo-1H-pyrrole-3-carboxylates (1a-e), known drug candidates for diabetic complications, were synthesized and proved to have in vitro insulin-mimetic activities, suggesting that these complexes are potential chemotherapeutics that are effective against both diabetes and diabetic complications.