Elsevier, Tetrahedron Letters, 26(55), p. 3581-3584, 2014
DOI: 10.1016/j.tetlet.2014.02.025
Wiley-VCH Verlag, ChemInform, 49(45), p. no-no, 2014
Full text: Unavailable
The one-pot reactions of aryl glyoxals with acetylacetone and urea using molybdate sulfuric acid (5 mol %) lead to the novel functionalized 5-acetyl-4-(aryloyl)-3,4-dihydropyrimidinones, which readily undergo the Knorr condensation with hydrazines to produce new pyrimido[4,5-d]pyridazines. The present strategies are in accordance with green chemistry principles through the use of a safe and recyclable catalyst under solvent-free conditions.