The present paper focuses on the various disturbance agents such as coal mining, limestone extraction, stone quarrying, jhum cultivation, fire, grazing, over-exploitation of resources, road constructions etc., affecting the natural growth of Nepethes khasiana in the Nokrek Biosphere Reserve of India. N. khasiana is the prominent insectivorous scandent shrubs species of this biosphere reserve and is an important source of medicine and basic ornamental uses for the local garo tribal people of north-east India. The inevitable pressure due to commercialization of the N. khasiana is leading to severe destruction of the species and may create the scarcity of that species in the near future. Therefore, joint efforts need to be implemented by the local garo villagers with governmental and non-governmental agencies for conservation and sustainable use of N. khasiana. The government may also take initiative by allotting demarcated forests areas to the villagers as village forest, thus motivating the villagers to take special care for its protection and rehabilitation and for a sustainable output.