A 51-year-old man incidentally felt an anterior midline cervical mass since 2 months before presentation. Both neck echogram and contrast-enhanced CT exposed a cystic lesion with slightly calcified soft tissue in anterior neck and small nodules in both lobes of the thyroid gland. F-18 FDG PET/CT revealed an intense uptake over the soft-tissue component of the cystic lesion, which was located in front of the hyoid bone. The patient subsequently received Sistrunk procedure, selective neck lymph node dissection, and total thyroidectomy. Pathology revealed papillary carcinoma in thyroglossal duct cyst and microcarcinoma in both lobes of the thyroid gland.