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American Thoracic Society, American Journal of Respiratory and Critical Care Medicine, 7(189), p. 853-859, 2014

DOI: 10.1164/rccm.201310-1896oc

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Bacillus Calmette-Guérin and Isoniazid Preventive Therapy Protect Contacts of Patients with Tuberculosis

Journal article published in 2014 by Jonathan L. Zelner, Megan B. Murray, Mercedes C. Becerra, Jerome Galea ORCID, Leonid Lecca ORCID, Roger Calderon ORCID, Rosa Yataco ORCID, Carmen Contreras, Zibiao Zhang, Bryan T. Grenfell, Ted Cohen ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Rationale: Individuals living with patients with tuberculosis (TB) are at elevated risk of infection and disease, with children at greatest risk. The World Health Organization recommends isoniazid preventive therapy (IPT) for HIV-positive contacts and those younger than 5 years. Despite these recommendations, household-level IPT programs are rarely implemented in high TB burden settings. Evidence is scarce about the age-specific efficacy of interventions, such as IPT and bacillus Calmette-Guérin (BCG) vaccination for preventing TB disease among exposed contacts.