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Oxford University Press, Nucleic Acids Research, suppl_2(39), p. W112-W117, 2011

DOI: 10.1093/nar/gkr357

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DARIO: a ncRNA detection and analysis tool for next-generation sequencing experiments

Journal article published in 2011 by M. (Mario) Fasold, D. (David) Langenberger ORCID, H. (Hans) Binder, P. (Peter) F F. Stadler ORCID, S. (Steve) Hoffmann
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Small non-coding RNAs (ncRNAs) such as microRNAs, snoRNAs and tRNAs are a diverse collection of molecules with several important biological functions. Current methods for high-throughput sequencing for the first time offer the opportunity to investigate the entire ncRNAome in an essentially unbiased way. However, there is a substantial need for methods that allow a convenient analysis of these overwhelmingly large data sets. Here, we present DARIO, a free web service that allows to study short read data from small RNA-seq experiments. It provides a wide range of analysis features, including quality control, read normalization, ncRNA quantification and prediction of putative ncRNA candidates. The DARIO web site can be accessed at http://dario.bioinf.uni-leipzig.de/.