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Hindawi, BioMed Research International, (2015), p. 1-11, 2015

DOI: 10.1155/2015/390863

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Diabetes and Its Link with Cancer: Providing the Fuel and Spark to Launch an Aggressive Growth Regime

Journal article published in 2014 by Sanket Joshi ORCID, Menghan Liu ORCID, Nigel Turner ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Diabetes is a disease involving metabolic derangements in multiple organs. While the spectrum of diabetic complications has been known for years, recent evidence suggests that diabetes could also contribute to the initiation and propagation of certain cancers. The mechanism(s) underlying this relationship are not completely resolved but likely involve changes in hormone and nutrient levels, as well as activation of inflammatory and stress-related pathways. Interestingly, some of the drugs used clinically to treat diabetes also appear to have antitumour effects, further highlighting the interaction between these two conditions. In this contribution we review recent literature on this emerging relationship and explore the potential mechanisms that may promote cancer in diabetic patients.