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Oxford University Press, SLEEP, 1(38), p. 73-84, 2015

DOI: 10.5665/sleep.4328

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Dexmedetomidine-Induced Sedation Does Not Mimic the Neurobehavioral Phenotypes of Sleep in Sprague Dawley Rat

Journal article published in 2014 by Abigail G. Garrity, Simhadri Botta, Stephanie B. Lazar, Erin Swor, Giancarlo Vanini, Helen A. Baghdoyan ORCID, Ralph Lydic ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Dexmedetomidine is used clinically to induce states of sedation that have been described as homologous to nonrapid eye movement (NREM) sleep. A better understanding of the similarities and differences between NREM sleep and dexmedetomidine-induced sedation is essential for efforts to clarify the relationship between these two states. This study tested the hypothesis that dexmedetomidine-induced sedation is homologous to sleep.