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Wiley, BJOG: An International Journal of Obstetrics and Gynaecology, 4(115), p. 532-537, 2008

DOI: 10.1111/j.1471-0528.2007.01624.x

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A preliminary study comparing the endometrial expression of inhibin, activin and follistatin in women with a history of implantation failure after IVF treatment and a control group

Journal article published in 2008 by A. Prakash, E. Tuckerman, S. Laird ORCID, B. Ola, Tc C. Li, Wl L. Ledger ORCID
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This paper is available in a repository.

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Abstract

The aim of this study was to evaluate the expression of activin: beta A and beta B subunit and follistatin in endometrium of women with implantation failure (n = 10) and compare it with a fertile control group (n = 7). Immunohistochemical staining intensity for follistatin in the endometrial glandular epithelium from women with implantation failure were significantly lower than that in control women (P = 0.03). The decreased expression of follistatin in epithelial cells in the endometrium of women with implantation failure after in vitro fertilisation (IVF) may suggest that follistatin may play a role in the implantation process.