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Oxford University Press (OUP), Bioinformatics, 18(28), p. i619-i625

DOI: 10.1093/bioinformatics/bts411

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From phenotype to genotype: an association study of longitudinal phenotypic markers to Alzheimer's disease relevant SNPs

Journal article published in 2012 by Hua Wang, Feiping Nie, Heng Huang, Jingwen Yan, Sungeun Kim, Kwangsik Nho, Shannon L. Risacher, Andrew J. Saykin, Li Shen ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Motivation: Imaging genetic studies typically focus on identifying single-nucleotide polymorphism (SNP) markers associated with imaging phenotypes. Few studies perform regression of SNP values on phenotypic measures for examining how the SNP values change when phenotypic measures are varied. This alternative approach may have a potential to help us discover important imaging genetic associations from a different perspective. In addition, the imaging markers are often measured over time, and this longitudinal profile may provide increased power for differentiating genotype groups. How to identify the longitudinal phenotypic markers associated to disease sensitive SNPs is an important and challenging research topic.