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Oxford University Press (OUP), Bioinformatics, 18(28), p. i495-i501

DOI: 10.1093/bioinformatics/bts410

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Boolean approach to signalling pathway modelling in HGF-induced keratinocyte migration

Journal article published in 2012 by Amit Singh ORCID, Juliana M. Nascimento ORCID, Silke Kowar, Hauke Busch, Melanie Boerries
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Motivation: Cell migration is a complex process that is controlled through the time-sequential feedback regulation of protein signalling and gene regulation. Based on prior knowledge and own experimental data, we developed a large-scale dynamic network describing the onset and maintenance of hepatocyte growth factor-induced migration of primary human keratinocytes. We applied Boolean logic to capture the qualitative behaviour as well as short-and long-term dynamics of the complex signalling network involved in this process, comprising protein signalling, gene regulation and autocrine feedback.