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Elsevier, NeuroImage: Clinical, (8), p. 560-571, 2015

DOI: 10.1016/j.nicl.2015.06.002

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Network analysis of EEG related functional MRI changes due to medication withdrawal in focal epilepsy

Journal article published in 2015 by Kees Hermans, Pauly Ossenblok, Petra van Houdt, Liesbeth Geerts, Rudolf Verdaasdonk, Paul Boon, Albert Colon, Jan C. de Munck
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Anti-epileptic drugs (AEDs) have a global effect on the neurophysiology of the brain which is most likely reflected in functional brain activity recorded with EEG and fMRI. These effects may cause substantial inter-subject variability in studies where EEG correlated functional MRI (EEG–fMRI) is used to determine the epileptogenic zone in patients who are candidate for epilepsy surgery. In the present study the effects on resting state fMRI are quantified in conditions with AED administration and after withdrawal of AEDs.