We present basic observational data and association membership analysis for 45 young and active low-mass stellar systems from the ongoing RECONS photometry and astrometry program at the Cerro Tololo Inter-American Observatory. Most of these systems have saturated X-ray emission (log(Lx/Lbol) > -3.5) based on X-ray fluxes from the ROSAT All-Sky Survey, and many are significantly more luminous than main-sequence stars of comparable color. We present parallaxes and proper motions, Johnson-Kron-Cousins VRI photometry, and multiplicity observations from the CTIOPI program on the CTIO 0.9m telescope. To this we add low-resolution optical spectroscopy and line measurements from the CTIO 1.5m telescope, and interferometric binary measurements from the Hubble Space Telescope Fine Guidance Sensors. We also incorporate data from published sources: JHKs photometry from the 2MASS point source catalog; X-ray data from the ROSAT All-Sky Survey; and radial velocities from literature sources. Within the sample of 45 systems, we identify 21 candidate low-mass pre-main-sequence members of nearby associations, including members of beta Pictoris, TW Hydrae, Argus, AB Doradus, two ambiguous 30 Myr old systems, and one object that may be a member of the Ursa Major moving group. Of the 21 candidate young systems, 14 are newly identified as a result of this work, and six of those are within 25 parsecs of the Sun. ; Comment: 40 pages, 11 tables, 20 figures. Accepted to AJ