Published in
Elsevier, Diagnostic Microbiology and Infectious Disease, 4(65), p. 447-449
DOI: 10.1016/j.diagmicrobio.2009.08.010
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In vivo selection of carbapenem-resistant Klebsiella pneumoniae by OmpK36 loss during meropenem treatment
Journal article published in 2009 by
Wonkeun Song,
Borum Suh,
Jun Yong Choi 
,
Seok Hoon Jeong,
Eun Hee Jeon,
Young Ki Lee,
Seong Geun Hong ,
Kyungwon Lee
,
Seok Hoon Jeong,
Eun Hee Jeon,
Young Ki Lee,
Seong Geun Hong ,
Kyungwon Lee
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Abstract
We recovered a carbapenem-resistant Klebsiella pneumoniae isolate H224 under in vivo meropenem selection pressure. Insertional inactivation of a major porin gene, ompK36, by IS5 element might play a role in acquiring carbapenem resistance in this strain harboring plasmid-borne DHA-1 AmpC beta-lactamase.