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Elsevier, Tetrahedron Letters, 34(55), p. 4697-4700, 2014

DOI: 10.1016/j.tetlet.2014.07.008

Wiley-VCH Verlag, ChemInform, 4(46), p. no-no, 2015

DOI: 10.1002/chin.201504122

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A one-pot tandem synthesis of various 1,2-disubstituted benzimidazoles

Journal article published in 2014 by Keng Yoon Yeong, Mohamed Ashraf Ali, Chee Wei Ang ORCID, Soo Choon Tan, Hasnah Osman
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

A facile method to synthesize various 1,2-disubstituted benzimidazoles is developed. It is suggested that formation of a Meisenheimer adduct between the substrate, amine, and solvent aids the N-arylation process. The generality of the protocol is demonstrated by the efficient reactions involving numerous substituents ranging from electron-withdrawing groups to electron-donating groups.