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Elsevier, Journal of Neuroimmunology, 1-2(226), p. 194-197, 2010

DOI: 10.1016/j.jneuroim.2010.07.003



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Association to the Glypican-5 gene in multiple sclerosis

This paper is available in a repository.
This paper is available in a repository.

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Data provided by SHERPA/RoMEO


Multiple sclerosis (MS) is an inflammatory, demyelinating disease affecting the central nervous system. MS-associated variants have been reported at both HLA and non-HLA loci, the latter including chromosome 13q31-32 and the Glypican-5 and Glypican-6 genes. In order to further explore the 13q31-32 region in MS, we genotyped 33 SNPs in 1355 Norwegian MS patients and 1446 Norwegian controls. An intronic SNP in the Glypican-5 gene (rs9523787) showed association with MS (p(corr)=0.006). Thus, this study supports that MS susceptibility at 13q31-32 may localize to the Glypican-5 gene, which should lead to further fine-mapping, replication and functional studies of this gene.