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Wiley, Molecular Nutrition & Food Research, 5(59), p. 879-893, 2015
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Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet-induced mouse model of nonalcoholic fatty liver disease
Journal article published in 2015 by
Sandra Pisonero-Vaquero,
Maria Victoria Garcia-Mediavilla,
Ángel Martínez-Ferreras,
María Victoria García-Mediavilla,
Susana Martínez-Flórez 
,
Anna Fernández,
Marta Benet,
Jose Luis Olcoz,
José Luis Olcoz,
Ramiro Jover,
Javier González-Gallego ,
Sonia Sánchez-Campos
,
Anna Fernández,
Marta Benet,
Jose Luis Olcoz,
José Luis Olcoz,
Ramiro Jover,
Javier González-Gallego ,
Sonia Sánchez-Campos
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Abstract
P. 879-893 ; Flavonoids and related compounds seem to have favorable effects on nonalcoholic fatty liver disease (NAFLD) progression, although the exact mechanisms implicated are poorly understood. In this study, we aimed to investigate the effect of the flanovol quercetin on gene expression deregulation involved in the development of NAFLD, as well as the possible implication of phosphatidylinositol 3-kinase (PI3K)/AKT pathway modulation