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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 1(54), p. 502-505, 2010

DOI: 10.1128/aac.00858-09

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Comparative Efficacies of Two Antimony Regimens To Treat Leishmania braziliensis-Induced Cutaneous Leishmaniasis in Rhesus Macaques (Macaca mulatta)

Journal article published in 2009 by G. Grimaldi, R. Porrozzi, K. Friedrich, A. Teva, R. S. Marchevsky, F. Vieira, N. Miekeley, F. J. R. Paumgartten ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT This study compared the efficacies of two N -methylglucomine antimoniate (MA) dose regimens for treating macaques with Leishmania braziliensis -induced chronic skin disease. Whereas all animals treated with the full dose (20 mg MA/kg/day) were cured, 50% of the monkeys receiving a low-dose regimen (5 mg MA/kg/day) relapsed. The antimony concentrations in macaque plasma and tissue samples were greater in the full-dose group than in that receiving a subtherapeutic MA regimen. Our data also suggest the presence of drug-induced hepatic pathology.