The densities (ρ ) and speeds of sound (u ) of betaine hydrochloride (B.HCl) drug (0.01 to 0.06) mol · kg−1 in (0.10, 0.20 and 0.30) mol · kg−1 aqueous d(+)-glucose and sucrose solutions are reported as a function of temperature at T = (293.15 to 313.15) K and atmospheric pressure. The values of density (ρ ) and speed of sound (u ) are obtained with high precision. These values have been used to estimate the apparent molar volume (V 2,ϕ ), partial molar volume (V2∞), transfer partial molar volume (ΔtV2∞), apparent molar isentropic compressibility (K s,2,ϕ ), partial molar isentropic compressibility (Ks,2∞), transfer partial molar compressibility (ΔtKs,2∞), hydration number (N H), partial molar expansion (E2∞) and Hepler’s constant (∂2V2∞/∂∂T 2)P. Furthermore, pair (V AB and K AB) and triplet (V ABB and K ABB) interaction coefficients have been computed from the values of ΔtV2∞ and ΔtKs,2∞. The co-sphere overlap model is used to understand the values of ΔtV2∞ and ΔtKs,2∞. The positive values of (∂2V2∞/∂∂T2)P indicate structure making ability of betaine hydrochloride in aqueous d(+)-glucose and sucrose solutions at the temperatures and compositions investigated.