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Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Journal article published in 2007 by Nm Walker, Ah H. Young, Ouwehand Wh, Ja A. Todd, Cc C. A. Spencer, Thilo Winzer, Nilesh J. Samani, Nc C. Taylor, Gr R. Walters, He E. Stevens, John A. Todd, Na A. Watkins, Nadira Yuldasheva, McArdle Wl, Dp P. Strachan and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), autoimmune thyroid disease (AITD), multiple sclerosis (MS) and breast cancer (BC). Comparing these data against a common control dataset derived from 1,500 randomly selected healthy British individuals, we report initial association and independent replication in a North American sample of two new loci related to ankylosing spondylitis, ARTS1 and IL23R, and confirmation of the previously reported association of AITD with TSHR and FCRL3. These findings, enabled in part by increased statistical power resulting from the expansion of the control reference group to include individuals from the other disease groups, highlight notable new possibilities for autoimmune regulation and suggest that IL23R may be a common susceptibility factor for the major 'seronegative' diseases. ; This paper was published as Nature Genetics, 2007, 39 (11), pp. 1329-1337. It is available from http://www.nature.com/ng/journal/v39/n11/abs/ng.2007.17.html. Doi: 10.1038/ng.2007.17 ; Metadata only entry