Genome-wide association study identifies eight loci associated with blood pressure

Zeleneka, Diana; Newton-Cheh, Christopher; Johnson, Toby; Najjar, Samar Ss; Gateva, Vesela; Van Der Harst, P.; Tobin, Martin D.; St Clair, D.; Voelker, Uwe; Volker, Uwe; Volzke, Henry; Zhao, Jing Hua; Bochud, Murielle; Heath, Simon C.; Coin, Lachlan; Eyheramendy, Susana; Voight, Benjamin F.; Wl, McArdle; Papadakis, Konstantinos; Timothy Bishop, D.; Scott, Laura J.; Zhang, Feng; Jc, Chambers; Wellcome Trust Case Control Consortium, Brown M Dominiczak A Newhouse SJ Samani NJ Webster J Zeggini E Beckmann JS Bergmann S Lim N Song K Vollenweider P Waeber G Waterworth DM Yuan X Groop L Orho-Melander M Allione A Di Gregorio A Guarrera S Panico S Ricceri F Romanazzi V Sacerdote C Vineis P B; Kt, Khaw; Farrall, Martin; Tanaka, Toshiko; Elliot, Ks; Wallace, Chris; Md, Tobin; De, Grobbee; Khaw, Kay-Tee; Nc, Onland Moret; Ml, Bots; van der Harst, Pim; Nilsson, Peter; Lv, Wain; Ks, Elliott; Pr, Burton; Polidoro, Silvia; Grobbee, Diederick E.; Ss, Najjar; Sj, Newhouse; Chambers, John C.; Onland-Moret, Nc Charlotte; Jh, Zhao; Wain, Louise V.; Nj, Samani; Sc, Heath; Elliott, Katherine S.; Van Gilst, Wh H.; Teumer, Alexander; Luan, Jian'an; Js, Beckmann; Lucas, Gavin; Tt, Valle; O’Donnell, Christopher J.; Bots, Michiel L.; Kuusisto, Johanna; Dm, Waterworth; McArdle, Wendy L.; Hadley, David; Erich Wichmann, H.; O’reilly, Paul F.; Newhouse, Stephen J.; Ms, Sandhu; Dominiczak, Anna; Burton, Paul R.; Samani, Nilesh J.; De Jong, Pe E.; Lj, Scott; Webster, John; Rn, Luben; Brown, Morris A.; Zeggini, Eleftheria; Doering, Angela; Gj, Crawford; Döring, Angela; Lim, Noha; Ll, Bonnycastle; Song, Kijoung; Waterworth, Dawn M.; Vollenweider, Peter; Bergmann, Sven; Fs, Collins; Waeber, Gerard; Beckmann, Jacques S.; Mark Lathrop, G.; Yuan, Xin; Kl, Mohlke; Hm, Stringham; Groop, Leif; Orho-Melander, Marju; Newton-Cheh C., Johnson T Gateva V Tobin MD Bochud M Coin L Najjar SS Zhao JH Heath SC Eyheramendy S Papadakis K Voight BF Scott LJ Zhang F Farrall M Tanaka T Wallace C Chambers JC Khaw KT Nilsson P van der Harst P Polidoro S Grobbee DE Onland-Moret NC Bots ML Wain LV Ell; Rn, Bergman; Ma, Morken; Di Gregorio, Alessandra; Thompson, John R.; Guarrera, Simonetta; Xue, M.; Panico, Salvatore; Eluosa, R.; Wallace, I.; Allione, Alessandra; Ricceri, Fulvio; Walker, Nm M.; Todd, Ja A.; Vineis, Paolo; Romanazzi, Valeria; Widmer, B.; Stevens, He E.; Sacerdote, Carlotta; He, Wichmann; Sandhu, Manjinder S.; Yt, van der Schouw; Luben, Robert N.; Sm, Schwartz; Cj, Willer; Barroso, Inês; Jousilahti, Pekka; Ds, Siscovick; Timpson, Nj; Perola, Markus; Stringham, Heather M.; Vannberg, F.; Jackson, Anne U.; Teo, Yy Y.; Crawford, Gabriel J.; Valle, Timo Tt; Mohlke, Karen L.; Lee, Kl L.; Willer, Cristen J.; Onipinla, A.; Boehnke, Michael; William, Rg G.; Bonnycastle, Lori Ll; Nb, Freimer; Doerr, Marcus; Collins, Francis S.; Dobson, Richard; Donnelly, Peter; Morken, Mario A.; Whittaker, P.; Dunger, Db B.; Withers, D.; Gungadoo, Johannie; Downes, K.; Leung, Hin-Tak; Mi, McCarthy; Gieger, Christian; Wichmann, He-Erich; Bingham, Sa A.; Illig, Thomas; Bf, Voight; Jones, Rw; Nutland, Sarah; Meitinger, Thomas; Dörr, Marcus; Bergman, Richard N.; Org, Elin; Kwiatkowski, Dp P.; O'Donnell, Christopher J.; Taylor, Nc C.; Pfeufer, Arne; Cj, O'Donnell; Doring, Angela; Winzer, Thilo; Watkins, Na A.; Schwartz, Stephen M.; de Jong, Paul E.; Davison, Dan; Siscovick, David S.; Kathiresan, Sekar; Morris, Ap P.; van Gilst, Wiek H.; Stevens, Suzanne; Marrugat, Jaume; Lindgren, Cm M.; Consortium, Wellcome Trust Case Control; Freimer, Nelson B.; Subirana, Isaac; Rayner, Nw W.; Evans, David; Hartikainen, Anna-Liisa; Lyons, E.; Hill, Avs V. S.; Su, Z.; Vukcevic, D.; McCarthy, Mark I.; O'Reilly, Paul F.; Rockett, Ka A.; Pf, O'Reilly; Walters, Gr R.; Ghori, J.; Peltonen, Leena; Pouta, Anneli; Hunt, Se E.; Pe, de Jong; Inouye, M.; Snieder, Harold; Keniry, E.; Bingham, Sheila A.; Wh, van Gilst; Syvänen, Ann-Christine; King, E.; Peden, John F.; Goel, Anuj; Braga Marcano, Ca A.; McGinnis, R.; Barke, B.; Hamsten, Anders; Clarke, Robert; Potter, S.; Lakatta, Edward G.; Young, Ah H.; Ravindrarajan, R.; Williamson, Richard; Jf, Peden; Groves, Cj J.; Seedorf, Udo; Tognoni, Giovanni; Clayton, Dg G.; Duncanson, Audrey; Ouwehand, Wh H.; Fraser, Christine; Jolley, Jennifer D.; Knight, As S.; Sanna, Serena; Koch, Kerstin; Cardon, Lr R.; Eg, Lakatta; Dorr, Marcus; Dixon, Rj J.; Barrett, Jc C.; Scheet, Paul; Yuldasheva, Nadira; Felix, Stephan B.; Ernst, Florian; Donnely, P.; Schlessinger, David; Au, Jackson; Pembrey, Marcus; Davidson, D.; Scuteri, Angelo; Homuth, Georg; Williams, Frances M.; Mangino, Massimo; Völker, Uwe; Marchini, Jl L.; Spencer, Ica C. A.; Tremelling, Mark; Ferreira, T.; Attwood, Ap P.; Zelenika, Diana; Pereira-Gale, J.; Hallgrimsdottir, Ib B.; Bryan, C.; van der Schouw, Yvonne T.; Howie, Bn N.; Lorbeer, Roberto; Moskvina, Valentina; Reffelmann, Thorsten; Bumpstead, Sj J.; Uiterwaal, Cuno S.; Craddock, N.; Forouhi, Nita G.; Deloukas, Panos; Chaney, A.; Rettig, Rainer; Elliott, Paul; Zhai, Guangju; Easton, Doug; Everson, Ursula; Hussey, Jm M.; Soranzo, Nicole; Meech, Elizabeth; Prowse, Cv; Galan, Pilar; Todhunter, Ce E.; Sb, Felix; Ring, Sm M.; Prembey, M.; Hercberg, Serge; Jones, Richard W.; O’donovan, Michael C.; Bentley, D.; Numans, Mattijs E.; Boorman, Jp P.; Mcguffin, Peter; Gordon-Smith, Katherine; Green, Ek K.; Völzke, Henry; Cant, Barbara; Salomaa, Veikko; Laakso, Markku; Jones, Lisa; Strachan, David P.; Hamshere, Ml L.; Symmons, Dpm P. M.; Worthington, J.; Grozeva, Detelina; Wareham, Nicholas J.; Holmans, Pa A.; Al, Hartikainen; Gut, Ivo G.; Lathrop, Gm Mark; Jones, Ir R.; Thomson, W.; Spector, Tim D.; Braund, Ps S.; Moskovina,; Nicol Ferrier, I.; Kirov, George; O'Donovan, Mc C.; Matullo, Giuseppe; Nikolov, Ivan; Weedon, Mn N.; Watkins, Hugh; Kooner, Jaspal S.; Owen, Mj J.; Ig, Gut; Walker, Neil M.; Navis, Gerjan; Elkin, Amanda; Cardin, Nj J.; Jarvelin, Marjo-Riitta; McGruffin, P.; Berglund, Göran; Farmer, Anne; Paterson, Andrew D.; Wordsworth, P.; Connell, John M.; Ferrier, In N.; Tuomilehto, Jaakko; Ferrucci, Luigi; Gm, Lathrop; Stratton, Mr R.; Loos, Ruth Jf F.; Iles, Mark Mm; Maqbool, Azhar; Hall, As S.; Elosua, Roberto; Breen, Gerome; Ac, Syvänen; Ceasar, S.; Parkes, Miles; Lees, Cw W.; Fm, Williams; Nimmo, Er R.; Altshuler, David; Bandinelli, Stefania; Drummond, Hazel; Munroe, Patricia B.; Ng, Forouhi; Fisher, Sa A.; Khalid Mohiuddin, M.; Uda, Manuela; Satsangi, Jack; Lewis, Cm M.; Cs, Uiterwaal; Laan, Maris; Craddock, Nick; Onnie, Cm M.; P., Deloukas; Prescott, Nj J.; Collier, Da A.; Mathew, Christopher G.; Forbes, Alastair; Me, Numans; Mathew, Cg; Meneton, Pierre; Sanderson, Jeremy; Mohiuddin, Mk K.; Ball, Sg G.; Melander, Olle; Balmforth, Aj J.; Mooser, Vincent; Mansfield, Jc C.; Barrett, Jh H.; Bishop, Dt T.; Jewell, Dp P.; Sa, Bingham; Charlotte Onland Moret, N.; Donovan, H.; Js, Kooner; Eyre, S.; Bredin, Francesca; Gilbert, Pd D.; Abecasis, Gonçalo R.; Bots Ml, Wain Lv; Hider, Sl L.; Jm, Connell; Hinks, Am M.; Caulfield, Mark J.; John, Sl L.; Potter, C.; Silman, Aj J.; Td, Spector; Frayling, Tm M.; Freathy, Rm M.; Barbour, Jamie; Lango, H.; Perry, Jrb R. B.; Hattersley, At T.; Cummings, Fr R.; Ahmad, Tariq; Dp, Strachan; Shields, Bm M.; Barton, A.; Hitman, Ga A.; Bruce, In N.; Newport, M.; Pb, Munroe; Sirugo, G.; Jallow, M.; Nj, Wareham; Pointon, Jl L.; Farrar, C.; Mr, Jarvelin; Franklyn, Ja A.; Heward, Jm M.; Simmonds, Mj J.; Ca Spencer, I.; Conway, D.; Seal, S.; Rahman, N.; Bradbury, La A.; Goris, A.; Rj, Loos; Caesar, Sian; Sawcer, Sj J.; Brown, Morris J.; Cough, Scl C. L.; Gr, Abecasis; Ban, M.; Burke, Beverley; Consor, Wellcome Trust Case Control; Compston, A.; ,

Dissemin
Toby Johnson
Zeleneka et al., 2009

Tools

Export citation

Format

@article{Zeleneka2009,
  abstract = {Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N ≤ 71,225 European ancestry, N ≤ 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N = 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 x 10-24), CYP1A2 (P = 1 x 10-23), FGF5 (P = 1 x 10-21), SH2B3 (P = 3 x 10-18), MTHFR (P = 2 x 10-13), c10orf107 (P = 1 x 10-9), ZNF652 (P = 5 x 10-9) and PLCD3 (P = 1 x 10-8) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease. ; This paper was published as Nature Genetics, 2009, 41 (6), pp. 666-676. It is available from http://www.nature.com/ng/journal/v41/n6/abs/ng.361.html. Doi: 10.1038/ng.361 ; Metadata only entry},
  author = {Zeleneka, Diana and Newton-Cheh, Christopher and Johnson, Toby and Najjar, Samar Ss and Gateva, Vesela and Van Der Harst, P. and Tobin, Martin D. and St Clair, D. and Voelker, Uwe and Volker, Uwe and Volzke, Henry and Zhao, Jing Hua and Bochud, Murielle and Heath, Simon C. and Coin, Lachlan and Eyheramendy, Susana and Voight, Benjamin F. and Wl, McArdle and Papadakis, Konstantinos and Timothy Bishop, D. and Scott, Laura J. and Zhang, Feng and Jc, Chambers and Wellcome Trust Case Control Consortium, Brown M Dominiczak A Newhouse SJ Samani NJ Webster J Zeggini E Beckmann JS Bergmann S Lim N Song K Vollenweider P Waeber G Waterworth DM Yuan X Groop L Orho-Melander M Allione A Di Gregorio A Guarrera S Panico S Ricceri F Romanazzi V Sacerdote C Vineis P B and Kt, Khaw and Farrall, Martin and Tanaka, Toshiko and Elliot, Ks and Wallace, Chris and Md, Tobin and De, Grobbee and Khaw, Kay-Tee and Nc, Onland Moret and Ml, Bots and van der Harst, Pim and Nilsson, Peter and Lv, Wain and Ks, Elliott and Pr, Burton and Polidoro, Silvia and Grobbee, Diederick E. and Ss, Najjar and Sj, Newhouse and Chambers, John C. and Onland-Moret, Nc Charlotte and Jh, Zhao and Wain, Louise V. and Nj, Samani and Sc, Heath and Elliott, Katherine S. and Van Gilst, Wh H. and Teumer, Alexander and Luan, Jian'an and Js, Beckmann and Lucas, Gavin and Tt, Valle and O’Donnell, Christopher J. and Bots, Michiel L. and Kuusisto, Johanna and Dm, Waterworth and McArdle, Wendy L. and Hadley, David and Erich Wichmann, H. and O’reilly, Paul F. and Newhouse, Stephen J. and Ms, Sandhu and Dominiczak, Anna and Burton, Paul R. and Samani, Nilesh J. and De Jong, Pe E. and Lj, Scott and Webster, John and Rn, Luben and Brown, Morris A. and Zeggini, Eleftheria and Doering, Angela and Gj, Crawford and Döring, Angela and Lim, Noha and Ll, Bonnycastle and Song, Kijoung and Waterworth, Dawn M. and Vollenweider, Peter and Bergmann, Sven and Fs, Collins and Waeber, Gerard and Beckmann, Jacques S. and Mark Lathrop, G. and Yuan, Xin and Kl, Mohlke and Hm, Stringham and Groop, Leif and Orho-Melander, Marju and Newton-Cheh C., Johnson T Gateva V Tobin MD Bochud M Coin L Najjar SS Zhao JH Heath SC Eyheramendy S Papadakis K Voight BF Scott LJ Zhang F Farrall M Tanaka T Wallace C Chambers JC Khaw KT Nilsson P van der Harst P Polidoro S Grobbee DE Onland-Moret NC Bots ML Wain LV Ell and Rn, Bergman and Ma, Morken and Di Gregorio, Alessandra and Thompson, John R. and Guarrera, Simonetta and Xue, M. and Panico, Salvatore and Eluosa, R. and Wallace, I. and Allione, Alessandra and Ricceri, Fulvio and Walker, Nm M. and Todd, Ja A. and Vineis, Paolo and Romanazzi, Valeria and Widmer, B. and Stevens, He E. and Sacerdote, Carlotta and He, Wichmann and Sandhu, Manjinder S. and Yt, van der Schouw and Luben, Robert N. and Sm, Schwartz and Cj, Willer and Barroso, Inês and Jousilahti, Pekka and Ds, Siscovick and Timpson, Nj and Perola, Markus and Stringham, Heather M. and Vannberg, F. and Jackson, Anne U. and Teo, Yy Y. and Crawford, Gabriel J. and Valle, Timo Tt and Mohlke, Karen L. and Lee, Kl L. and Willer, Cristen J. and Onipinla, A. and Boehnke, Michael and William, Rg G. and Bonnycastle, Lori Ll and Nb, Freimer and Doerr, Marcus and Collins, Francis S. and Dobson, Richard and Donnelly, Peter and Morken, Mario A. and Whittaker, P. and Dunger, Db B. and Withers, D. and Gungadoo, Johannie and Downes, K. and Leung, Hin-Tak and Mi, McCarthy and Gieger, Christian and Wichmann, He-Erich and Bingham, Sa A. and Illig, Thomas and Bf, Voight and Jones, Rw and Nutland, Sarah and Meitinger, Thomas and Dörr, Marcus and Bergman, Richard N. and Org, Elin and Kwiatkowski, Dp P. and O'Donnell, Christopher J. and Taylor, Nc C. and Pfeufer, Arne and Cj, O'Donnell and Doring, Angela and Winzer, Thilo and Watkins, Na A. and Schwartz, Stephen M. and de Jong, Paul E. and Davison, Dan and Siscovick, David S. and Kathiresan, Sekar and Morris, Ap P. and van Gilst, Wiek H. and Stevens, Suzanne and Marrugat, Jaume and Lindgren, Cm M. and Consortium, Wellcome Trust Case Control and Freimer, Nelson B. and Subirana, Isaac and Rayner, Nw W. and Evans, David and Hartikainen, Anna-Liisa and Lyons, E. and Hill, Avs V. S. and Su, Z. and Vukcevic, D. and McCarthy, Mark I. and O'Reilly, Paul F. and Rockett, Ka A. and Pf, O'Reilly and Walters, Gr R. and Ghori, J. and Peltonen, Leena and Pouta, Anneli and Hunt, Se E. and Pe, de Jong and Inouye, M. and Snieder, Harold and Keniry, E. and Bingham, Sheila A. and Wh, van Gilst and Syvänen, Ann-Christine and King, E. and Peden, John F. and Goel, Anuj and Braga Marcano, Ca A. and McGinnis, R. and Barke, B. and Hamsten, Anders and Clarke, Robert and Potter, S. and Lakatta, Edward G. and Young, Ah H. and Ravindrarajan, R. and Williamson, Richard and Jf, Peden and Groves, Cj J. and Seedorf, Udo and Tognoni, Giovanni and Clayton, Dg G. and Duncanson, Audrey and Ouwehand, Wh H. and Fraser, Christine and Jolley, Jennifer D. and Knight, As S. and Sanna, Serena and Koch, Kerstin and Cardon, Lr R. and Eg, Lakatta and Dorr, Marcus and Dixon, Rj J. and Barrett, Jc C. and Scheet, Paul and Yuldasheva, Nadira and Felix, Stephan B. and Ernst, Florian and Donnely, P. and Schlessinger, David and Au, Jackson and Pembrey, Marcus and Davidson, D. and Scuteri, Angelo and Homuth, Georg and Williams, Frances M. and Mangino, Massimo and Völker, Uwe and Marchini, Jl L. and Spencer, Ica C. A. and Tremelling, Mark and Ferreira, T. and Attwood, Ap P. and Zelenika, Diana and Pereira-Gale, J. and Hallgrimsdottir, Ib B. and Bryan, C. and van der Schouw, Yvonne T. and Howie, Bn N. and Lorbeer, Roberto and Moskvina, Valentina and Reffelmann, Thorsten and Bumpstead, Sj J. and Uiterwaal, Cuno S. and Craddock, N. and Forouhi, Nita G. and Deloukas, Panos and Chaney, A. and Rettig, Rainer and Elliott, Paul and Zhai, Guangju and Easton, Doug and Everson, Ursula and Hussey, Jm M. and Soranzo, Nicole and Meech, Elizabeth and Prowse, Cv and Galan, Pilar and Todhunter, Ce E. and Sb, Felix and Ring, Sm M. and Prembey, M. and Hercberg, Serge and Jones, Richard W. and O’donovan, Michael C. and Bentley, D. and Numans, Mattijs E. and Boorman, Jp P. and Mcguffin, Peter and Gordon-Smith, Katherine and Green, Ek K. and Völzke, Henry and Cant, Barbara and Salomaa, Veikko and Laakso, Markku and Jones, Lisa and Strachan, David P. and Hamshere, Ml L. and Symmons, Dpm P. M. and Worthington, J. and Grozeva, Detelina and Wareham, Nicholas J. and Holmans, Pa A. and Al, Hartikainen and Gut, Ivo G. and Lathrop, Gm Mark and Jones, Ir R. and Thomson, W. and Spector, Tim D. and Braund, Ps S. and Moskovina,  and Nicol Ferrier, I. and Kirov, George and O'Donovan, Mc C. and Matullo, Giuseppe and Nikolov, Ivan and Weedon, Mn N. and Watkins, Hugh and Kooner, Jaspal S. and Owen, Mj J. and Ig, Gut and Walker, Neil M. and Navis, Gerjan and Elkin, Amanda and Cardin, Nj J. and Jarvelin, Marjo-Riitta and McGruffin, P. and Berglund, Göran and Farmer, Anne and Paterson, Andrew D. and Wordsworth, P. and Connell, John M. and Ferrier, In N. and Tuomilehto, Jaakko and Ferrucci, Luigi and Gm, Lathrop and Stratton, Mr R. and Loos, Ruth Jf F. and Iles, Mark Mm and Maqbool, Azhar and Hall, As S. and Elosua, Roberto and Breen, Gerome and Ac, Syvänen and Ceasar, S. and Parkes, Miles and Lees, Cw W. and Fm, Williams and Nimmo, Er R. and Altshuler, David and Bandinelli, Stefania and Drummond, Hazel and Munroe, Patricia B. and Ng, Forouhi and Fisher, Sa A. and Khalid Mohiuddin, M. and Uda, Manuela and Satsangi, Jack and Lewis, Cm M. and Cs, Uiterwaal and Laan, Maris and Craddock, Nick and Onnie, Cm M. and P., Deloukas and Prescott, Nj J. and Collier, Da A. and Mathew, Christopher G. and Forbes, Alastair and Me, Numans and Mathew, Cg and Meneton, Pierre and Sanderson, Jeremy and Mohiuddin, Mk K. and Ball, Sg G. and Melander, Olle and Balmforth, Aj J. and Mooser, Vincent and Mansfield, Jc C. and Barrett, Jh H. and Bishop, Dt T. and Jewell, Dp P. and Sa, Bingham and Charlotte Onland Moret, N. and Donovan, H. and Js, Kooner and Eyre, S. and Bredin, Francesca and Gilbert, Pd D. and Abecasis, Gonçalo R. and Bots Ml, Wain Lv and Hider, Sl L. and Jm, Connell and Hinks, Am M. and Caulfield, Mark J. and John, Sl L. and Potter, C. and Silman, Aj J. and Td, Spector and Frayling, Tm M. and Freathy, Rm M. and Barbour, Jamie and Lango, H. and Perry, Jrb R. B. and Hattersley, At T. and Cummings, Fr R. and Ahmad, Tariq and Dp, Strachan and Shields, Bm M. and Barton, A. and Hitman, Ga A. and Bruce, In N. and Newport, M. and Pb, Munroe and Sirugo, G. and Jallow, M. and Nj, Wareham and Pointon, Jl L. and Farrar, C. and Mr, Jarvelin and Franklyn, Ja A. and Heward, Jm M. and Simmonds, Mj J. and Ca Spencer, I. and Conway, D. and Seal, S. and Rahman, N. and Bradbury, La A. and Goris, A. and Rj, Loos and Caesar, Sian and Sawcer, Sj J. and Brown, Morris J. and Cough, Scl C. L. and Gr, Abecasis and Ban, M. and Burke, Beverley and Consor, Wellcome Trust Case Control and Compston, A. and , },
  doi = {10.1038/ng.361},
  month = {may},
  title = {Genome-wide association study identifies eight loci associated with blood pressure},
  url = {http://www.nature.com/articles/ng.361.pdf},
  year = {2009}
}

Download

Export citation

Search in Google Scholar

Genome-wide association study identifies eight loci associated with blood pressure

Journal article published in 2009 by Diana Zeleneka, Christopher Newton-Cheh, Toby Johnson

, Samar Ss Najjar, Vesela Gateva, P. Van Der Harst, Martin D. Tobin, D. St Clair, Uwe Voelker, Uwe Volker, Henry Volzke, Jing Hua Zhao, Murielle Bochud, Simon C. Heath, Lachlan Coin, Susana Eyheramendy, Benjamin F. Voight, McArdle Wl, Konstantinos Papadakis, D. Timothy Bishop, Laura J. Scott, Feng Zhang, Chambers Jc, Brown M Dominiczak A Newhouse SJ Samani NJ Webster J Zeggini E Beckmann JS Bergmann S Lim N Song K Vollenweider P Waeber G Waterworth DM Yuan X Groop L Orho-Melander M Allione A Di Gregorio A Guarrera S Panico S Ricceri F Romanazzi V Sacerdote C Vineis P B Wellcome Trust Case Control Consortium, Khaw Kt, Martin Farrall, Toshiko Tanaka, Ks Elliot, Chris Wallace, Tobin Md, Grobbee De, Kay-Tee Khaw, Onland Moret Nc, Bots Ml, Pim van der Harst, Peter Nilsson, Wain Lv, Elliott Ks, Burton Pr, Silvia Polidoro, Diederick E. Grobbee, Najjar Ss, Newhouse Sj, John C. Chambers, Nc Charlotte Onland-Moret, Zhao Jh, Louise V. Wain

, Samani Nj, Heath Sc, Katherine S. Elliott, Wh H. Van Gilst, Alexander Teumer, Jian'an Luan, Beckmann Js, Gavin Lucas, Valle Tt, Christopher J. O’Donnell, Michiel L. Bots, Johanna Kuusisto, Waterworth Dm, Wendy L. McArdle, David Hadley, H. Erich Wichmann, Paul F. O’reilly, Stephen J. Newhouse, Sandhu Ms, Anna Dominiczak, Paul R. Burton, Nilesh J. Samani, Pe E. De Jong, Scott Lj, John Webster, Luben Rn, Morris A. Brown, Eleftheria Zeggini

, Angela Doering, Crawford Gj, Angela Döring, Noha Lim, Bonnycastle Ll, Kijoung Song, Dawn M. Waterworth, Peter Vollenweider, Sven Bergmann, Collins Fs, Gerard Waeber, Jacques S. Beckmann, G. Mark Lathrop, Xin Yuan, Mohlke Kl, Stringham Hm, Leif Groop, Marju Orho-Melander, Johnson T Gateva V Tobin MD Bochud M Coin L Najjar SS Zhao JH Heath SC Eyheramendy S Papadakis K Voight BF Scott LJ Zhang F Farrall M Tanaka T Wallace C Chambers JC Khaw KT Nilsson P van der Harst P Polidoro S Grobbee DE Onland-Moret NC Bots ML Wain LV Ell Newton-Cheh C., Bergman Rn, Morken Ma, Alessandra Di Gregorio, John R. Thompson, Simonetta Guarrera, M. Xue, Salvatore Panico, R. Eluosa, I. Wallace, Alessandra Allione, Fulvio Ricceri, Nm M. Walker, Ja A. Todd, Paolo Vineis, Valeria Romanazzi, B. Widmer, He E. Stevens, Carlotta Sacerdote, Wichmann He, Manjinder S. Sandhu, van der Schouw Yt, Robert N. Luben

, Schwartz Sm, Willer Cj, Inês Barroso, Pekka Jousilahti, Siscovick Ds, Nj Timpson, Markus Perola, Heather M. Stringham, F. Vannberg, Anne U. Jackson, Yy Y. Teo, Gabriel J. Crawford, Timo Tt Valle, Karen L. Mohlke, Kl L. Lee, Cristen J. Willer, A. Onipinla, Michael Boehnke, Rg G. William, Lori Ll Bonnycastle, Freimer Nb, Marcus Doerr, Francis S. Collins, Richard Dobson, Peter Donnelly, Mario A. Morken, P. Whittaker, Db B. Dunger, D. Withers, Johannie Gungadoo, K. Downes, Hin-Tak Leung, McCarthy Mi, Christian Gieger

, He-Erich Wichmann, Sa A. Bingham, Thomas Illig, Voight Bf, Rw Jones, Sarah Nutland, Thomas Meitinger, Marcus Dörr, Richard N. Bergman, Elin Org, Dp P. Kwiatkowski, Christopher J. O'Donnell, Nc C. Taylor, Arne Pfeufer, O'Donnell Cj, Angela Doring, Thilo Winzer, Na A. Watkins, Stephen M. Schwartz, Paul E. de Jong, Dan Davison, David S. Siscovick, Sekar Kathiresan, Ap P. Morris, Wiek H. van Gilst, Suzanne Stevens, Jaume Marrugat, Cm M. Lindgren, Wellcome Trust Case Control Consortium, Nelson B. Freimer, Isaac Subirana, Nw W. Rayner, David Evans, Anna-Liisa Hartikainen, E. Lyons, Avs V. S. Hill, Z. Su, D. Vukcevic, Mark I. McCarthy, Paul F. O'Reilly, Ka A. Rockett, O'Reilly Pf, Gr R. Walters, J. Ghori, Leena Peltonen, Anneli Pouta, Se E. Hunt, de Jong Pe, M. Inouye, Harold Snieder, E. Keniry, Sheila A. Bingham, van Gilst Wh, Ann-Christine Syvänen, E. King, John F. Peden, Anuj Goel, Ca A. Braga Marcano, R. McGinnis, B. Barke, Anders Hamsten, Robert Clarke, S. Potter, Edward G. Lakatta, Ah H. Young, R. Ravindrarajan, Richard Williamson, Peden Jf, Cj J. Groves, Udo Seedorf

, Giovanni Tognoni, Dg G. Clayton, Audrey Duncanson, Wh H. Ouwehand, Christine Fraser, Jennifer D. Jolley, As S. Knight, Serena Sanna

, Kerstin Koch, Lr R. Cardon, Lakatta Eg, Marcus Dorr, Rj J. Dixon, Jc C. Barrett, Paul Scheet, Nadira Yuldasheva, Stephan B. Felix, Florian Ernst, P. Donnely, David Schlessinger, Jackson Au, Marcus Pembrey, D. Davidson, Angelo Scuteri, Georg Homuth, Frances M. Williams, Massimo Mangino, Uwe Völker, Jl L. Marchini, Ica C. A. Spencer, Mark Tremelling, T. Ferreira, Ap P. Attwood, Diana Zelenika, J. Pereira-Gale, Ib B. Hallgrimsdottir, C. Bryan, Yvonne T. van der Schouw

, Bn N. Howie, Roberto Lorbeer, Valentina Moskvina, Thorsten Reffelmann, Sj J. Bumpstead, Cuno S. Uiterwaal, N. Craddock, Nita G. Forouhi, Panos Deloukas

, A. Chaney, Rainer Rettig, Paul Elliott, Guangju Zhai, Doug Easton, Ursula Everson, Jm M. Hussey, Nicole Soranzo, Elizabeth Meech, Cv Prowse, Pilar Galan, Ce E. Todhunter, Felix Sb, Sm M. Ring, M. Prembey, Serge Hercberg, Richard W. Jones, Michael C. O’donovan, D. Bentley, Mattijs E. Numans, Jp P. Boorman, Peter Mcguffin, Katherine Gordon-Smith, Ek K. Green, Henry Völzke, Barbara Cant, Veikko Salomaa, Markku Laakso, Lisa Jones, David P. Strachan, Ml L. Hamshere, Dpm P. M. Symmons, J. Worthington, Detelina Grozeva, Nicholas J. Wareham, Pa A. Holmans, Hartikainen Al, Ivo G. Gut, Gm Mark Lathrop, Ir R. Jones, W. Thomson, Tim D. Spector, Ps S. Braund, Moskovina, I. Nicol Ferrier, George Kirov, Mc C. O'Donovan, Giuseppe Matullo, Ivan Nikolov, Mn N. Weedon, Hugh Watkins, Jaspal S. Kooner, Mj J. Owen, Gut Ig, Neil M. Walker, Gerjan Navis, Amanda Elkin, Nj J. Cardin, Marjo-Riitta Jarvelin, P. McGruffin, Göran Berglund, Anne Farmer, Andrew D. Paterson, P. Wordsworth, John M. Connell, In N. Ferrier, Jaakko Tuomilehto, Luigi Ferrucci, Lathrop Gm, Mr R. Stratton, Ruth Jf F. Loos, Mark Mm Iles, Azhar Maqbool, As S. Hall, Roberto Elosua, Gerome Breen, Syvänen Ac, S. Ceasar, Miles Parkes, Cw W. Lees, Williams Fm, Er R. Nimmo, David Altshuler, Stefania Bandinelli, Hazel Drummond, Patricia B. Munroe, Forouhi Ng, Sa A. Fisher, M. Khalid Mohiuddin, Manuela Uda, Jack Satsangi, Cm M. Lewis, Uiterwaal Cs, Maris Laan

, Nick Craddock, Cm M. Onnie, Deloukas P., Nj J. Prescott

, Da A. Collier, Christopher G. Mathew, Alastair Forbes, Numans Me, Cg Mathew, Pierre Meneton, Jeremy Sanderson, Mk K. Mohiuddin, Sg G. Ball, Olle Melander, Aj J. Balmforth, Vincent Mooser, Jc C. Mansfield, Jh H. Barrett, Dt T. Bishop, Dp P. Jewell, Bingham Sa, N. Charlotte Onland Moret, H. Donovan, Kooner Js, S. Eyre, Francesca Bredin, Pd D. Gilbert, Gonçalo R. Abecasis, Wain Lv Bots Ml, Sl L. Hider, Connell Jm, Am M. Hinks, Mark J. Caulfield, Sl L. John, C. Potter, Aj J. Silman, Spector Td, Tm M. Frayling, Rm M. Freathy, Jamie Barbour, H. Lango, Jrb R. B. Perry, At T. Hattersley, Fr R. Cummings

, Tariq Ahmad, Strachan Dp, Bm M. Shields, A. Barton, Ga A. Hitman, In N. Bruce, M. Newport, Munroe Pb, G. Sirugo, M. Jallow, Wareham Nj, Jl L. Pointon, C. Farrar, Jarvelin Mr, Ja A. Franklyn, Jm M. Heward, Mj J. Simmonds, I. Ca Spencer, D. Conway, S. Seal, N. Rahman, La A. Bradbury, A. Goris, Loos Rj, Sian Caesar, Sj J. Sawcer, Morris J. Brown, Scl C. L. Cough, Abecasis Gr, M. Ban, Beverley Burke, Wellcome Trust Case Control Consor, A. Compston,

Show less

This paper is available in a repository.

Full text: Download

Preprint: policy unknown

Upload

Postprint: policy unknown

Upload

Published version: policy unknown

Upload

Abstract

Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N ≤ 71,225 European ancestry, N ≤ 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N = 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 x 10-24), CYP1A2 (P = 1 x 10-23), FGF5 (P = 1 x 10-21), SH2B3 (P = 3 x 10-18), MTHFR (P = 2 x 10-13), c10orf107 (P = 1 x 10-9), ZNF652 (P = 5 x 10-9) and PLCD3 (P = 1 x 10-8) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease. ; This paper was published as Nature Genetics, 2009, 41 (6), pp. 666-676. It is available from http://www.nature.com/ng/journal/v41/n6/abs/ng.361.html. Doi: 10.1038/ng.361 ; Metadata only entry

Links

Tools

Genome-wide association study identifies eight loci associated with blood pressure

Abstract