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Oxford University Press, Nucleic Acids Research, Web Server(37), p. W465-W468, 2009

DOI: 10.1093/nar/gkp363

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TOPCONS: Consensus prediction of membrane protein topology

Journal article published in 2009 by Andreas Bernsel, Håkan Viklund, Aron Hennerdal, Arne Elofsson ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

TOPCONS (http://topcons.net/) is a web server for consensus prediction of membrane protein topology. The underlying algorithm combines an arbitrary number of topology predictions into one consensus prediction and quantifies the reliability of the prediction based on the level of agreement between the underlying methods, both on the protein level and on the level of individual TM regions. Benchmarking the method shows that overall performance levels match the best available topology prediction methods, and for sequences with high reliability scores, performance is increased by ∼10 percentage points. The web interface allows for constraining parts of the sequence to a known inside/outside location, and detailed results are displayed both graphically and in text format.