Published in

Nature Research, Scientific Reports, 1(4), 2014

DOI: 10.1038/srep03730

Links

Tools

Export citation

Search in Google Scholar

L-dopa-induced dyskinesia: Beyond an excessive dopamine tone in the striatum

Journal article published in 2014 by Gregory Porras, Philippe De Deurwaerdere, Qin Li, Matteo Marti ORCID, Rudolf Morgenstern, Reinhard Sohr, Erwan Bezard ORCID, Michele Morari, Wassilios G. Meissner
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Red circle
Postprint: archiving forbidden
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

L-dopa remains the mainstay treatment for Parkinson's disease (PD), although in later stages, treatment is complicated by L-dopa-induced dyskinesias (LID). Current evidence links LID to excessive striatal L-dopa-derived dopamine (DA) release, while the possibility of a direct involvement of L-dopa itself in LID has been largely ignored. Here we show that L-dopa can alter basal ganglia activity and produce LID without enhancing striatal DA release in parkinsonian non-human primates. These data may have therapeutic implications for the management of advanced PD since they suggest that LID could result from diverse mechanisms of action of L-dopa.