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MDPI, Molecules, 7(16), p. 6116-6128, 2011

DOI: 10.3390/molecules16076116

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Ruthenium-Catalyzed Selective Hydrogenation of bis-Arylidene Tetramic Acids. Application to the Synthesis of Novel Structurally Diverse Pyrrolidine-2,4-diones

Journal article published in 2011 by Christos S. Karaiskos, Dimitris Matiadis ORCID, John Markopoulos, Olga Igglessi-Markopoulou
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Catalytic hydrogenation of 3,5-bis-arylidenetetramic acids, known for their biological activity, has been developed. The chemoselective ruthenium-catalyzed reduction of the exocyclic carbon-carbon double bonds on pyrrolidine-2,4-dione ring system, containing other reducible functions, has been investigated. Depending on the substrate the yield of the hydrogenation process can reach up to 95%. The structural elucidation has been established using NMR and HRMS spectral data.