Published in
American Chemical Society, Organic Letters, 17(3), p. 2757-2759, 2001
DOI: 10.1021/ol0163629
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Sterically Demanding, Water-Soluble Alkylphosphines as Ligands for High Activity Suzuki Coupling of Aryl Bromides in Aqueous Solvents
Journal article published in 2001 by
Kevin H. Shaughnessy 
,
Rebecca S. Booth
,
Rebecca S. Booth
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Abstract
[reaction: see text]. Sterically demanding, water-soluble alkylphosphines have been found to give highly active catalysts for Suzuki coupling of aryl bromides in aqueous solvents. A variety of aryl bromides and boronic acids were coupled in excellent yield. Turnover numbers up to 734 000 mmol/mmol Pd have been achieved under mild conditions.