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Springer Nature [academic journals on nature.com], Blood Cancer Journal, 2(4), p. e188-e188, 2014

DOI: 10.1038/bcj.2014.10

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Incidence and prognostic significance of karyotypic subgroups in older patients with acute myeloid leukemia: the Swedish population-based experience

Journal article published in 2014 by V. Lazarevic ORCID, A.-S. Horstedt, A.-S. Hörstedt, B. Johansson, Petar Antunovic, R. Billstrom, A. Derolf, Å. Derolf, E. Hulegardh, S. Lehmann, L. Mollgard, C. Nilsson ORCID, S. Peterson, D. Stockelberg, B. Uggla and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The Swedish population-based acute myeloid leukemia registry contains data from 3251 patients (excluding acute promyelocytic leukemia) diagnosed between 1997 and 2006. Informative cytogenetic data from 1893 patients were retrospectively added, including 1054 patients aged between 60 and 79 years. Clonal abnormalities were found in 57% of the informative karyotypes. Karyotypic patterns differed by age: t(8; 21), inv(16) and t(11q23) were more common in younger patients, whereas loss of 5q, 7q and 17p, monosomal karyotype (MK) and complex karyotypes were more common in older patients. Loss of 5q, 7q and 17p often occurred together within MK. Patients with greater than= 5 chromosome abnormalities had worse overall survival than those with fewer abnormalities or normal karyotype in all age groups. Loss of 5q, 7q and/or 17p had, in contrast to MK, a further negative impact on survival. Multivariable Cox regression analyses on risk factors in patients less than80 years with cytogenetic abnormalities and intensive treatment revealed that age and performance status had the most significant impact on survival (both Pless than0.001), followed by sex (P = 0.0135) and a karyotype including - 7/del(7q) (P = 0.048).