The immune system has evolved to protect an organism against a wide variety of infectious agents, including viruses, fungi, bacteria, and multicellular parasites. These pathogens employ many different strategies to survive and multiply in the host, which can lead directly or indirectly to pathology because they interfere with homeostasis or function of affected cells and tissues. However, the immune system is quite adept in facing and handling the threats imposed by these pathogens, using an array of specialized cells and effector mechanisms. In this issue of Immunity, Lin et al. (2009) describe a unique way in which the immune system uses the strengths of two T cell subsets to eliminate the intracellular pathogen Francisella tularensis.