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Springer Nature [academic journals on nature.com], Molecular Psychiatry, 9(8), p. 770-772, 2003

DOI: 10.1038/sj.mp.4001329

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Inconsistent designs of association studies: A missed opportunity

Journal article published in 2003 by T. G. Schulze, J. Hardy, F. J. McMahon ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Genetic association mapping is a powerful tool to detect susceptibility genes for complex disorders, even when each of these genes has small contribution to risk. Given the lack of Consistency across studies, particularly of psychiatric diseases, it is imperative to develop and agree upon standards for the design and report of genetic association studies. The authors propose standards of general study design, diagnostic assessment, genotyping, and statistical analysis, which could enhance the comparability of future genetic association studies.