We present a preliminary study which explores the potential of aggregation-induced emission (AIE) luminogen as a new fluorescent probe for STED microscopy. Compared with Coumarin 102, which is a commonly used organic fluorophore in STED microscopy, HPS, a typical AIE luminogen, is more resistant to photobleaching. In addition, HPS-doped nanoparticles have higher emission depletion efficiency than Coumarin 102 in organic solution. These two advantages of AIE luminogen can facilitate the improvement of spatial resolution, as well as long-term imaging, in STED microscopy. AIE luminogen will be a promising candidate for STED microscopy in the future.