Published in
Elsevier, International Journal of Medical Microbiology, 6(290), p. 519-527, 2000
DOI: 10.1016/s1438-4221(00)80017-x
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Pathogenicity islands and phage conversion: Evolutionary aspects of bacterial pathogenesis
Journal article published in 2000 by
Ulrich Dobrindt,
Joachim Reidl 
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Abstract
Horizontal gene transfer plays a key role in the generation of novel bacterial pathogens. Besides plasmids and bacteriophages, large genomic regions termed pathogenicity islands (PAIs) can be transferred horizontally. All three mechanisms for DNA exchange or transfer may be important for the evolution of bacterial pathogens.