Horseradish peroxidase (HRP) is a well-known and commercially available enzyme that has been used over the last years in a wide range of applications from which one can emphasize its leading role in organic synthesis with direct influence in the medical field. This review highlights the versatility of this enzyme, pointing out the work developed in biocatalysis research that provide new interesting products supported in green sustainable methodologies. Therefore, the goal is not to deeply explore the issues related to the mechanistic concepts of the reactions, but to use some selected examples to show the broad range of compounds that can be obtained in reactions with HRP, evidencing its use mainly in organic synthesis.