Published in
Wiley, Angewandte Chemie International Edition, 37(50), p. 8745-8749, 2011
Wiley, Angewandte Chemie, 37(123), p. 8904-8908, 2011
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An Acyclic Oligoheteroaryle That Discriminates Strongly between Diverse G-Quadruplex Topologies
,
Jean-Francois Riou,
Chi-Hung Nguyen,
Marie-Paule Teulade-Fichou
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Abstract
Feeling groovy: A family of nonmacrocyclic G-quadruplex binders with alternate oxazole and pyridine motifs was prepared. The shown heptacyclic derivative exhibits an unprecedented binding preference for certain quadruplex topologies: it recognizes exclusively the human telomeric quadruplex in Na + buffer but not in K + buffer. This unique quadruplex binding profile is strongly dependent on the size of the ligand and may result from groove interactions.