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Tuberculosis: laboratory diagnosis and treatment strategies, p. 232-242

DOI: 10.1079/9781845938079.0232

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Therapy of the XDR-TB Patient with Thioridazine – An Old Drug with New Applications.

Journal article published in 2013 by Leonard Amaral, Marta Martins, Isabel Couto, M. Viveiros ORCID, And
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

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Abstract

AbstractThis chapter provides the rationale and experimental basis for considering thioridazine (an inexpensive neuroleptic drug used for over 40 years) as a new effective drug for treatment of extensively drug-resistant tuberculosis (XDR-TB). The development of antibiotic resistance in Mycobacterium tuberculosis, the criteria for an effective anti-MDR/XDR-TB, anti-latent M. tuberculosis agent, and the antituberculosis activity of phenothiazines are described.