Published in
Elsevier, Journal of Investigative Dermatology, 5(131), p. 1003-1005, 2011
DOI: 10.1038/jid.2011.14
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New Psoriasis Susceptibility Genes: Momentum for Skin-Barrier Disruption
Journal article published in 2011 by
Eliecer Coto,
Jorge Santos-Juanes,
Pablo Coto-Segura,
Victoria Alvarez 
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Abstract
The epidermal differentiation complex gene cluster is on chromosome region 1q21.3, where the PSORS4 locus was mapped. A common deletion of two LCE genes (LCE3C_LCE3B-del) was associated with psoriasis. Individuals homozygous for the deletion have an impaired response of the skin barrier to exogenous agents, facilitating the systemic skin inflammation characteristic of psoriasis.