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American Society for Microbiology, Journal of Bacteriology, 23(192), p. 6295-6301, 2010

DOI: 10.1128/jb.00853-10

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The Staphylococcus aureus Autoinducer-2 Synthase LuxS Is Regulated by Ser/Thr Phosphorylation

Journal article published in 2010 by Marie-Eve Cluzel, Isabelle Zanella-Cléon, Alain J. Cozzone, Klaus Fütterer ORCID, Bertrand Duclos, Virginie Molle
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The Staphylococcus aureus autoinducer-2 (AI-2) producer protein LuxS is phosphorylated by the Ser/Thr kinase Stk1 at a unique position, Thr14. The enzymatic activity of the phosphorylated isoform of LuxS was abrogated compared to that of nonphosphorylated LuxS, thus providing the first evidence of an AI-2-producing enzyme regulated by phosphorylation and demonstrating that S. aureus possesses an original and specific system for controlling AI-2 synthesis. Copyright © 2010, American Society for Microbiology. All Rights Reserved.