Published in
Elsevier, Bioorganic and Medicinal Chemistry Letters, 7(12), p. 1071-1074
DOI: 10.1016/s0960-894x(02)00080-x
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Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase
Journal article published in 2002 by
Patrizia Alberti,
Philippe Schmitt,
Chi-Hung Nguyen,
Christian Rivalle,
Magali Hoarau,
David S. Grierson,
David S. Grierson,
Jean-Louis Mergny 
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Abstract
Telomeric G-rich single-stranded DNA can adopt a G-tetraplex structure which has been shown to inhibit telomerase activity. We have examined benzoindoloquinolines derivatives for their ability to stabilize an intramolecular G-quadruplex. The increase in T(m) value of the G-quadruplex was associated with telomerase inhibition in vitro.