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Wiley-VCH Verlag, ChemInform, 49(43), p. no-no, 2012

DOI: 10.1002/chin.201249108

Elsevier, Tetrahedron, 31(68), p. 6146-6151

DOI: 10.1016/j.tet.2012.05.079

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Active methylene compounds in a very effective approach to 3-substituted isobenzofuranones through tandem aldol/lactonization reactions

This paper is available in a repository.
This paper is available in a repository.

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Abstract

In this article we describe a new accessible methodology for the synthesis of isobenzofuran-1(3H)-ones. In this process we exploited an effective, economic, useful and environmentally benign K2CO3 catalyzed, solvent-free one-pot tandem aldol-lactonization reaction between active methylene compounds and methyl 2-carboxy benzaldehyde. A particularly simple work-up and purification procedure are additional advantages addressed to a general green chemistry approach to this important class of heterocyclic compounds.