Wiley-VCH Verlag, ChemInform, 49(43), p. no-no, 2012
Elsevier, Tetrahedron, 31(68), p. 6146-6151
DOI: 10.1016/j.tet.2012.05.079
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In this article we describe a new accessible methodology for the synthesis of isobenzofuran-1(3H)-ones. In this process we exploited an effective, economic, useful and environmentally benign K2CO3 catalyzed, solvent-free one-pot tandem aldol-lactonization reaction between active methylene compounds and methyl 2-carboxy benzaldehyde. A particularly simple work-up and purification procedure are additional advantages addressed to a general green chemistry approach to this important class of heterocyclic compounds.