Dysregulated expression of Bcl-xL in CD34+ cells isolated from patients with refractory anemia with excess of blasts during megakaryocytic differentiation
Journal article published in 2003 by
Maurizio Martini 
,
Myriam Luongo,
Luciana Teofili,
Antonella Di Mario,
Giuseppe Leone ,
Luigi Maria Larocca
,
Myriam Luongo,
Luciana Teofili,
Antonella Di Mario,
Giuseppe Leone ,
Luigi Maria Larocca
Abstract
We investigated whether autocrine transforming growth factor-β1 (TGF-β1) production modulates Bcl-xL expression during megakaryocytic differentiation of CD34+ cells isolated from normal individuals from patients with refractory anemia with excess of blasts (RAEB). We found that autocrine TGF-β1 production up-regulates Bcl-xL expression in normal megakaryocytopoiesis, and that this pathway is altered in RAEB cells.